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post in: Health, News, Video Date:12 Oct 2017, 04:33 views:1544
Pre-pregnancy maternal obesity is associated with adverse asthma offspring outcomes at birth and later in life. Individual studies have shown that epigenetic modifications such as DNA methylation could contribute. Within the Pregnancy and Childhood Epigenetics (pace) Consortium, we meta-ysed the association between pre-pregnancy maternal BMI and methylation at over 450,000 sites in newborn blood DNA, across 19 cohorts (9,340 mother-newborn pairs).
We attempted to infer causality by comparing the effects of asthma maternal versus paternal BMI and incorporating genetic variation. In four additional cohorts (1,817 mother-child pairs we meta-ysed the association between maternal BMI at the start of pregnancy and blood methylation in adolescents.
In newborns, maternal BMI was associated with small (.2 per BMI unit (1 kg/m2 P .06 10-7) methylation variation at 9,044 sites throughout the genome. Adjustment for estimated cell proportions greatly attenuated the number of significant CpGs to 104, including 86 sites common to the unadjusted model.
At 72/86 sites, the direction of the association was the same in newborns and adolescents, suggesting persistence of signals. However, we found evidence for acausal intrauterine effect of maternal BMI on newborn methylation at just 8/86 sites.
In conclusion, this well-powered ysis identified robust associations between maternal adiposity and variations in newborn blood DNA methylation, but these small effects may be better explained by genetic or lifestyle factors than a causal intrauterine mechanism.
This highlights the need for large-scale collaborative approaches and the application of causal inference techniques in epigenetic epidemiology. Pollen food allergy syndrome.
TTTuberk Toraks 2017; 65(2 138-145, pollen food allergy syndrome, is a type I cross-reaction mediated by IgE antibodies between an aeroallergen and a plant-derived antigen. Main symptoms are typically consist of localized oral symptoms.
Pollen food allergy syndrome, is a type I cross-reaction mediated by IgE antibodies between an aeroallergen and a plant-derived antigen. Main symptoms are typically consist of localized oral symptoms such as numbness of the lip or mouth, itching, tingling and swelling of lips, tongue, palate and pharynx without systemic symptoms. Patients with seasonal allergic rhinitis, asthma or both more frequently experience pollen food allergy syndrome.
Because most patients have mild symptoms and the improvement by avoiding food, the true incidence is unknown. In this review, we aimed to discuss characteristics, diagnosis and treatment of pollen food allergy syndrome according to existing literature.
Electronic Cigarettes: Their Constituents and Potential Links to Asthma. CACurr Allergy Asthma Rep 2017 Oct 05; 17(11.