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post in: Lifestyle Date:08 Oct 2017, 13:56 views:2624
Mohamed Noureldin 1, Medhat Haroun 2, Iman Diab 3, Sabah Elbanna 4, Nashwa Abdelwahab 5 1Department of Pharmacology and Toxicology, Faculty of pharmacy, Pharos University, Alexandria, Egypt 2Department of Biotechnology, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt 3Department of Medical Biochemistry, Faculty. Correspondence to: Mohamed Noureldin, Department of Pharmacology and Toxicology, Faculty of pharmacy, Pharos University, Alexandria, Egypt.
Email: Copyright 2014 Scientific Academic Publishing. Abstract, background : Asthma is a chronic, inflammatory disease of the respiratory tract, which is characterized by bronchial hyperreactivity and respiratory obstruction in which many cells and cellular elements play a role.
Interleukin 13 (IL-13) is a type 2 helper T cells (Th2) cytokine that has been shown to be pivotal in the induction of allergic inflammation of the airways.
Moreover, Several IL-13 genetic polymorphisms have been linked with susceptibility to bronchial asthma.
Aim : The aim of this study was to evaluate the association of IL-13 2044G/A polymorphism remedy with bronchial asthma development, severity and total serum immunoglobulin E (IgE) levels in Egyptian patients with bronchial asthma. Subjects and methods : This study included 50 asthmatic patients and 30 controls. Restriction Fragment Length Polymorphism (rflp) PCR was used for the ysis of the studied polymorphism.
Also, the serum was yzed for total IgE levels by enzyme-linked immunosorbent assay (elisa).
Results : The frequency of the A allele was significantly higher in asthmatic patients as compared to control subjects. On the contrary, the G allele was less frequent in the asthmatic patients as compared to control subjects. In addition the A allele was more frequent in severe asthmatic patients and on the other hand the G allele was less frequent in severe asthmatic patients.
Moreover, the presence of the A allele was significantly associated with higher total serum IgE levels whether in homozygous or heterozygous state. Conclusions : The results showed that the IL-13 2044 A allele is a risk factor for bronchial asthma. There is a significant association between the A allele and more severe asthma, however the G allele is significantly associated with less severe asthma.
In addition, the A allele is significantly associated with higher total serum IgE levels. Keywords: IL-13 polymorphism, Genetics, IgE, Asthma development.