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post in: Lifestyle, Health Date:14 Oct 2017, 10:29 views:2546
Current corticosteroid regimens for children hospitalized with asthma typically include a 5-day course of prednisone or prednisolone.
However, these medications taste poorly and are associated with vomiting and poor compliance.
Outpatient evidence suggests that a 2-day course of dexamethasone is asthma as effective as a longer course of prednisone and prednisolone, and better tolerated.
Studies in hospitalized patients are lacking.
The investigators' primary objective is to determine the feasibility of a non-inferiority trial, comparing 2 days of dexamethasone to 4 days of inpatient prednisone/prednisolone for inpatient asthma treatment. The investigators also wish to determine the feasibility of 1) enrolling patients upon admission to hospital, 2) asking patients and/or caregivers to complete a symptom weekly for 4 weeks, 3) reassessing patients post hospital discharge, 4) successfully completing phone follow up 4 weeks post hospital. This study will inform a future multi-site trial comparing prednisone/prednisolone to dexamethasone in inpatient asthma treatment.
It has the potential of improving the delivery of care in asthma, by improving compliance with a mainstay of treatment. It will also enhance collaboration within Ontario pediatric hospitals, facilitating knowledge translation and standardization of care across institutions. Further study details as provided by Catherine Pound, Children's Hospital of Eastern Ontario.
Prednisone acts quickly to help people dealing with severe asthma and coughing attacks.
It does this by subduing the swelling that asthma causes.
Normally, taking prednisone for only a week will not result in any severe side effects, but that does not mean you do not need to give up other treatments. Prednisone is an oral synthetic steroid that is used for the treatment of inflammatory conditions. Is It Safe to Use Prednisone for Asthma?
Usually, steroids are prescribed when the use of other drugs are not giving the desired results. Prescription Drug Abuse FactsPrescription drug abuse involves the use of prescription drugs in a manner other than what has. Corticosteroids have been used to treat asthma for approximately 50 years.