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Immune mediated factor asthma and allergy

post in: Lifestyle, Beauty, News Date:08 Oct 2017, 09:37 views:2242

Immune mediated factor asthma and allergy

Allergic asthma is the most common form of asthma. . In allergic asthma asthma, the body initiates an immune response to an allergen such as pet dander, dust-mites, mold or pollen that allergy results in IgE antibodies. . This process is commonly referred to as allergic sensitization. .

Most allergens are proteins (can be a carbohydrate or lipid) that pass through the epithelial barrier and come into contact with a dendritic cell. . The dendritic cell presents the antigen peptide to Nave T cells in the context of major histocompatibility complex (MHC) class II molecules. .

This is recognized by a Nave T cell that can become an allergen-specific T helper 2 (Th2) cell that will secrete the cytokines IL-4 and IL-13 necessary for the activation of B cells to produce IgE antibodies. . Circulating IgE antibodies attach to the surface of mast cells and basophils via its high affinity receptor for IgE (FceRI) and/or continue to re-circulate throughout the body. .

Subsequent exposure to the same allergen will cause cross-linking of the cell-bound antigen specific IgE, which causes degranulation and the release of mediators. Mediators include histamine, prostaglandins and leukotrienes. .

Additionally, the reaction can be enhanced by the recruitment of eosinophils. . Ultimately the mediators promote vascular permeability, smooth-muscle contraction and mucus production, which cause symptoms of asthma including airway constriction, coughing, shortness of breath and wheezing.

Suggested review institute articles from the literature: The development of allergic inflammation Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma Ovalbumin (OVA) induced allergic asthma: Ovalbumin (OVA) is widely used to induce an IgE response in mouse models of allergic asthma. .

Endpoint ysis may include evaluating airway hyperresponsiveness, eosinophil count of the bronchoalveolar lavage (BAL) and the quantification of ytes in serum and BAL fluid. .

MD Bioproducts offers an elisa kit for endpoint ysis. OVA-IgE - a marker of an OVA induced asthmatic response.

 

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