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post in: Lifestyle Date:17 Oct 2017, 06:00 views:4853
Updated: July 2015, originally Posted: May 2006, updated by: Nataliya M Kushnir, MD faaaai. Medical Director, Allergy and Immunology Clinic of asthma East Bay. Berkeley, California, distinguished Volunteer Teacher, Oakland Childrens Hospital Residency Program.
Kaliner, MD faaaai, medical Director, Institute for Asthma and Allergy. Chevy Chase and Wheaton, Maryland, professor of Medicine, George Washington University School of Medicine.
Washington DC, original authors:. Henry Li, MD, PhD, faaaai, facaai. Institute for Asthma and Allergy, wheaton and Chevy Chase Maryland, michael.
Washington DC, definition and demographics, asthma is truly a syndrome encompassing several disease entities/endotypes. The word asthma derives from the Greek word for panting, or breathlessness, and thus describes the primary symptom of this disease.
Asthma is recognized as a complex condition with differences in severity, natural history, comorbidities, and treatment response. It has been defined as "a chronic inflammatory disorder associated with variable airflow obstruction and bronchial hyperresponsiveness.
It presents with recurrent episodes of wheeze, cough, shortness of breath, chest tightness.". While the critical role of inflammation has been further drugs substantiated, there is an evidence for considerable variability in the pattern of inflammation indicating phenotypic differences that may influence treatment responses.
Gene-by-environmental interactions are important to the development and expression of asthma.
Of the environmental factors, allergic reactions and pollution are of critical importance with expanding role for viral respiratory infections in these processes.
The onset of asthma for most patients begins early in life with the pattern of disease persistence determined by early, recognizable risk factors including atopic disease, recurrent wheezing, and a parental history of asthma. Current asthma treatment with anti-inflammatory does not appear to prevent progression of the underlying disease severity.
The most recent comprehensive yses of the Global Burden of Disease Study (GBD) undertaken in estimates the number of people with asthma in the world as high as 334 million. A lower figure of 235 million used in the Global Asthma Report 2011 came from the most up-to-date GBD information available at that time based on yses from.