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Manufacturer: Zoetis methylprednisolone acetate sterile aqueous suspension 20 mg per mL and 40 mg per. For Use in Animals Only, depo-Medrol Caution, federal (USA) law restricts this drug to school use by or on the order of a licensed veterinarian. These preparations are recommended for immunol intramuscular and intrasynovial injection in horses and dogs, and intramuscular injection in cats.
Depo-medrol Sterile Aqueous Suspension is available in two allergy concentrations, 20 mg per mL and 40 mg per.
Each mL of these preparations contains: 20 mg 40 mg, methylprednisolone acetate 20 mg 40 mg, polyethylene glycol 3350.6 mg 29 mg, sodium chloride.9.7. Myristyl-gamma-picolinium chloride added as preservative.198.195 mg, when necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid. Clinical Pharmacology, metabolic And Hormonal Effects, methylprednisolone, an anti-inflammatory steroid synthesized and developed in the Research Laboratories of The Upjohn Company, is the 6-methyl derivative of prednisolone.
Exceeding prednisolone in anti-inflammatory potency and having even less tendency than prednisolone to induce sodium and water retention, methylprednisolone offers the advantage over older corticosteroids of affording equally satisfactory anti-inflammatory effect with the use of lower doses and with an enhanced split between anti-inflammatory and. Estimates of the relative potencies of methylprednisolone and prednisolone range from.13.1, with an average.5. In anti-inflammatory activity, as measured by the granuloma pouch assay, methylprednisolone is twice as active as prednisolone.
In mineralocorticoid activity (ie, the capacity to induce retention of sodium and water in the adrenalectomized rat) methylprednisolone is slightly less active than prednisolone. The duration of plasma steroid levels following rapid intravenous injection in intact dogs is appreciably longer for methylprednisolone than for prednisolone, the respective half-life value for the two steroids being.9.5 minutes for methylprednisolone and.3.7 minutes for prednisolone.
While the effect of parenterally administered depo-medrol is prolonged, it has the same metabolic and anti-inflammatory actions as orally administered methylprednisolone acetate. Depo-Medrol Indications And Usage. As with other adrenal steroids, depo-medrol Sterile Aqueous Suspension has been found useful in alleviating the pain and lameness associated with acute localized arthritic conditions and generalized arthritic conditions.
It has been used successfully to treat rheumatoid arthritis, traumatic arthritis, osteoarthritis, periostitis, tendinitis, synovitis, tenosynovitis, bursitis, and myositis of horses; traumatic arthritis, osteoarthritis, and generalized arthritic conditions of dogs. Remission of musculoskeletal conditions may be permanent, or symptoms may recur, depending on the cause and extent of structural degeneration. This preparation is especially beneficial in relieving pruritus and inflammation of allergic dermatitis, acute moist dermatitis, dry eczema, urticaria, bronchial asthma, pollen sensitivities and otitis externa in dogs; allergic dermatitis and moist and dry eczema in cats.
Onset of relief may begin within a few hours to a few days following injection and may persist for a few days to six weeks.
Symptoms may be expected to recur if the cause of the allergic reaction is still present, in which case retreatment may be indicated. In treating acute hypersensitivity reactions, such as anaphylactic shock, intravenous solu-delta-cortef Sterile Powder containing prednisolone sodium succinate, as well as other appropriate treatments, should be used. Overwhelming Infections with Severe Toxicity.