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Fairfield county allergy and asthma

post in: Lifestyle, Video Date:23 Aug 2017, 07:14 views:1269

Fairfield county allergy and asthma


Researchers have shown that a wearable patch that delivers small amounts of peanut protein through the skin has yielded promising results for treating children and young adults with peanut allergy, with greater benefits for younger children, according to one-year results from an ongoing clinical trial. Journal of Allergy and Clinical Immunology.

The treatment, called epicutaneous immunotherapy or epit, was found to be safe and well-tolerated, and nearly all participants used the skin patch daily as directed. The ongoing trial is sponsored alabama by the National Institute of Allergy and Infectious Diseases (niaid part of the National Institutes of Health, and conducted by the niaid-funded Consortium of Food Allergy Research (CoFAR which is led by Hugh Sampson, MD, of Icahn School of Medicine. Stacie Jones, MD, of the University of Arkansas for Medical Sciences and Arkansas Childrens Hospital, chairs the study.

To avoid potentially life-threatening allergic reactions, people with peanut allergy must be vigilant about the foods they eat and the environments they enter, which can be very stressful, said niaid Director asthma Anthony. One goal of experimental approaches such as epicutaneous immunotherapy is to reduce this burden by training the immune system to tolerate enough peanut to protect against accidental ingestion or exposure. CoFAR researchers at five study sites randomly assigned 74 peanut-allergic volunteers aged 4 to 25 years to treatment with either a high-dose (250 micrograms peanut protein low-dose (100 micrograms peanut protein or placebo patch.

The investigators assessed peanut allergy at the beginning of the study with a supervised, oral food challenge with peanut-containing food. The patches were developed and provided by the biopharmaceutical company DBV Technologies under the trade name Viaskin. Each day, study participants applied a new patch to their arm or between their shoulder blades.

After one year, researchers assessed each participants ability to consume at least 10 times more peanut protein than he or she was able to consume before starting epit. The low-dose and high-dose regimens were found to offer similar benefits, with 46 of the low-dose group and 48 of the high-dose group achieving treatment success, compared with 12 of the placebo group.

In addition, the peanut patches induced immune responses similar to those seen with other investigational forms of immunotherapy for food allergy. Investigators observed greater treatment effects among children aged 4 to 11 years, with significantly less effect in participants aged 12 years and older.

The clinical benefit seen in younger children highlights the promise of this innovative approach to treating peanut allergy, said Daniel Rotrosen, MD, director of niaids Division of Allergy, Immunology and Transplantation (dait). Epicutaneous immunotherapy aims to engage the immune system in the skin to train the body to tolerate small amounts of allergen, whereas other recent advances have relied on an oral route that appears difficult for approximately 10 to 15 of children and adults to tolerate.

 

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