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post in: News Date:02 Oct 2017, 10:33 views:3318
Background: The Gly-to-Arg substitution at the 16 position (rs1042713) in the 2-adrenoceptor gene (adrb2) is associated with enhanced downregulation and uncoupling of 2-receptors. Objectives: We sought to undertake a meta-ysis to test the hypothesis that there is an interaction between the A allele of rs1042713 (Arg16 amino acid) and long-acting -agonist (laba) exposure for asthma exacerbations in children.
Methods: Children with diagnosed asthma were recruited in 5 populations (breathe, Genes-Environments and Admixture in Latino Americans II, pacman, the Paediatric Asthma Gene Environment Study, and the Pharmacogenetics of Adrenal Suppression with Inhaled Steroid Study). A history of recent exacerbation and asthma treatment was determined from questionnaire data.pulmonary
DNA was extracted, and the Gly16Arg genotype was determined. Results: Data from 4226 children of white Northern European and Latino origin were yzed, and the odds ratio for exacerbation increased.52 (95 CI,.17-1.99;.0021) for each copy of the A allele among the 637 children treated with inhaled corticosteroids (ICSs) plus labas but. Conclusions: The use of a laba but not an ltra as an "add-on controller" is associated with increased risk of asthma exacerbation in children carrying 1 or 2 A alleles at rs1042713.
Prospective genotype-stratified clinical trials are now required to explore the potential role of rs1042713 genotyping for personalized asthma therapy in children. Copyright 2015 American Academy of Allergy, Asthma Immunology. Published by Elsevier Inc.
The Scottish Centre for Respiratory Research childhood was set up in 1997 and is led by Brian Lipworth, Professor of Allergy and Pulmonology. The group comprises. Asthma Allergy Research Group Division of Molecular Clinical Medicine Mailbox.
School of Medicine Ninewells Hospital Medical School Dundee. Departmental pages at Dundee University.
Prize for asthma research. Team within the Asthma and Allergy Research Group are currently evaluating new and.
(2)Asthma Allergy Research Group, Medical Research Institute, University of Dundee. Childhood asthma exacerbations and the Arg16 2-receptor polymorphism. ( 11)Asthma and Allergy Research Group, University of Dundee.