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post in: Products, Lifestyle Date:19 Oct 2017, 05:03 views:1865
Asthma is a potentially life-threatening condition in which patients experience bronchial spasms that obstruct the airway. More allergy often than not, the telltale wheezing and shortness of breath are center caused by the immune systems reacting to allergens, but occasionally asthma is induced by physical activity.
Asthma is a global health problem, affecting over 200 million people worldwide. There is no cure for asthma: patients cope with it by avoiding allergens or activities that trigger it and often rely heavily on inhaled or oral corticosteroids to open airways in case of asthmatic attack.
Patients with asthma routinely show high levels of inflammatory Th2 cytokine proteins in their bloodstream, so-named because they are secreted by immune cells called Th2 helper cells.
These messenger molecules exacerbate asthma and other allergies, making them a target for drug treatment: some patients who dont respond to common treatments are helped by treatment with monoclonal antibodies targeting Th2 cytokines.
Ample evidence supports the idea that heightened Th2 cell signaling is the cellular signature of allergy and asthma. Thus, several LJI investigators are searching for genes or proteins that either foment or subdue Th2 cell activity in affected patients.
Genome-wide ysis, in that effort, LJI scientist Pandurangan Vijayanand,.D.,.
D, recently applied next-generation computational approaches to take a global snapshot of gene expression in both Th1 and Th2 cells.
To do so, he surveyed the entire genome of both asthmatic and control non-asthmatic individuals for short stretches of DNA called enhancers, which switch target genes on and off. This ysis, conducted with LJIs Bjoern Peters,. D., and Anjana Rao,.
D., identified a manageable number of genes inappropriately switched on in Th2 cells of asthmatic patients, factors that could potentially serve as novel therapeutic targets.
T helper signaling whips up francisco the inflammation that drives asthmatic attacks. But the cellular perpetrators are mast cells, which release the histamine actually provokes physiological symptoms.