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Manchester asthma and allergy study maas

post in: ´╗┐Products, Lifestyle Date:05 Oct 2017, 08:00 views:4218

Manchester asthma and allergy study maas

Children who receive antibiotics before their first birthday might be at a slightly increased risk of developing asthma. However, new research by The University of Manchester suggests that it is impaired viral immunity and genetic variants on a region of chromosome 17 that increase the risk of both antibiotic use in early life and later asthma rather than the antibiotics themselves, as previously.

Importantly, the study, which was funded by the Medical Research Council and oulton Charitable Foundation did not find a link between early antibiotic prescription and the development of allergic reactions. The findings, reported in, the Lancet Respiratory Medicine today (15 May contradict the prevailing theory that early antibiotic exposure, via changes in gut flora, alters the development of a childs immune system, increasing susceptibility to allergic asthma later. In children, antibiotics are routinely used to treat respiratory infections, ear infections, and bronchitis, and several studies have reported a link between the use of antibiotics during early childhood and the subsequent development of asthma.

However, systematic reviews have reported conflicting results and called for additional longitudinal studies to provide definitive answers. In this study, UK researchers examined data from the Manchester Asthma and Allergy Study (maas) which has followed over 1000 children from birth to 11 years.

Information on antibiotic prescription, wheeze and asthma exacerbations medications were taken from medical records. Skin reaction tests that show whether a child is hypersensitive to allergens were done at ages 3, 5, 8, and 11 years. At age 11, blood was collected from children who had received at least one course of antibiotics or no antibiotics in the first year of life to compare their immune-system cell asthma response to viruses (rhinovirus; the virus responsible for the common cold, and respiratory syncytial.

Genetic testing was also done to look at the links between common genetic variations on chromosome 17, known as 17q21, and antibiotic prescription. The studys findings are believed to be the first to show that children with wheezing who were treated with an antibiotic in the first year of life were more than twice as likely as untreated children to experience severe wheeze or asthma exacerbations and.

Similarly, these children also showed significantly lower induction of cytokines, which are the bodies key defence against virus infections such as the common cold.

However, no differences were noted in antibacterial responses. The researchers also identified two genes in the 17q21 region that were associated with an increased risk of early life antibiotic prescription. Lead author Professor Adnan Custovic, from the Institute of Inflammation and Repair based at The University of Manchester, said: We speculate that hidden factors which increase the likelihood of both antibiotic prescription in early life and subsequent asthma are an increased susceptibility to viral infections.

 

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